Platinum-based antitumor drugs have been used in many types of tumors due to its broad
antitumor spectrum in clinic. Encouraged by the cisplatin's (CDDP) worldwide success in …

Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as
DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP …

Abstract PARP (poly (ADP-ribose) polymerase) inhibitors (PARPi) have demonstrated
significant potential in cancer treatment, particularly in tumors with breast cancer …

In this commentary, using existing clinical trial data and FDA approvals we propose that
there is currently a critical need for an appropriate balancing between the financial impact of …

In recent years, poly (ADP-ribose) polymerase (PARP) inhibition has become a promising
therapeutic option for several tumors, especially for those harboring a BRCA 1–2 mutation or …

Chemotherapeutic metallodrugs such as cisplatin and its derivatives are among the most
widely applied anticancer treatments worldwide. Despite their clinical success, patients …

The application of new synthetic methods in the area of platinum (IV) anticancer prodrugs
greatly increases the availability of accessible chemical entities that can be conjugated to …

Platinum (Pt) drugs have developed rapidly in clinical applications because of their broad
and highly effective antitumor effects. In recent years, with the rapid development of …

Octahedral Pt (IV) prodrugs are an effective way to combine cisplatin-like moieties and a
second drug to obtain selective and stimuli responsive bifunctional antiproliferative …

Among gynecological cancers, ovarian cancer causes the most fatalities. Currently, cisplatin
is a potent chemotherapy used for treatment. However, cisplatin efficacy remains limited due …