Parkinson's disease (PD) is a neurodegenerative disease characterized by the
degeneration of dopaminergic neurons in the substantia nigra (SN); the etiology and …

Sepsis-induced myocardial dysfunction (SIMD) is one of the serious health-affecting
problems worldwide. At present, the mechanisms of SIMD are still not clearly elucidated. The …

NLRP3 inflammasome was introduced as a double-edged sword in tumorigenesis and
influenced immunotherapy response by modulating host immunity. However, a systematic …

Polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF)
are rare hematological conditions known as myeloproliferative neoplasms (MPNs). They are …

Toll‐like receptors (TLRs) and inflammasomes belong to the pattern recognition receptors
(PRRs) of innate immunity identifying conserved compounds produced by pathogens or …

Hematopoietic stem cells (HSCs) regularly produce various blood cells throughout life via
their self-renewal, proliferation, and differentiation abilities. Most HSCs remain quiescent in …

Motivation Gaining a comprehensive understanding of the genetics underlying cancer
development and progression is a central goal of biomedical research. Its accomplishment …

Background NOD-like receptor proteins (NLRs) are essential innate pattern recognition
receptors that play fundamental roles in inflammation, and they have been associated with …

Background: Inflammasomes are related to tumorigenesis and immune-regulation. Here, we
investigated the prognostic value of the NLR family pyrin domain containing (NLRP) …

Inflammasomes are fundamental innate immune mechanisms that promote inflammation
and induce an inflammatory form of programmed cell death, pyroptosis. Pyroptotic …