Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found
throughout the CNS, constituting approximately 5% of all CNS cells and persisting from …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics,
are becoming powerful tools for profiling of cellular states in the tissue context,,,–. However …

Probing histone modifications at a single-cell level in thousands of cells has been enabled
by technologies such as single-cell CUT&Tag. Here we describe nano-CUT&Tag (nano-CT) …

Oligodendrocytes are best known for wrapping myelin, a unique specialization that enables
energy-efficient and fast axonal impulse propagation in white matter tracts and fibers of the …

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination of the
central nervous system (CNS). Autologous hematopoietic cell transplantation (HCT) shows …

Oligodendrocyte precursor cells (OPCs) are a central nervous system resident population of
glia with a distinct molecular identity and an ever-increasing list of functions. OPCs generate …

Translating genome-wide association study (GWAS) loci into causal variants and genes
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …

Axonal degeneration determines the clinical outcome of multiple sclerosis and is thought to
result from exposure of denuded axons to immune-mediated damage. Therefore, myelin is …

Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a
robust, but poorly understood, neuroinflammatory response that contributes to the long-term …