Simple Summary Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a
multifunctional tumor suppressor with protein-and lipid-phosphatase activities. The …

Background Inheritance patterns show familial clustering of gastrointestinal cancers, and
multiple germline conditions have now been identified that predispose to colorectal, gastric …

Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …

Simple Summary Colorectal cancer (CRC) in adolescents and young adults (AYA) is rare.
Genetic causes include autosomal recessive and dominant monogenic disorders due to …

Screening for Lynch syndrome (LS) in colorectal cancer (CRC) and endometrial cancer
patients generally involves immunohistochemical staining of the mismatch repair (MMR) …

Infiltrating ductal adenocarcinoma of the pancreas, referred to here as “pancreatic cancer,” is
one of the deadliest of all of the solid malignancies. The five-year survival rate in the United …

Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and
is caused by pathogenic constitutional variants in 1 of the mismatch repair (MMR) genes …

Introduction Lynch syndrome (LS) is a hereditary condition that increases the risk of
colorectal (CRC) and extracolonic cancers that exhibit microsatellite instability (MSI‐H). MSI …

Simple Summary Lynch syndrome (LS) stands as the predominant inherited cancer
condition at present. Currently, surveillance is based on genotype-driven strategies and …

Abstract In the Drug Rediscovery Protocol (DRUP), patients with cancer are treated based
on their tumor molecular profile with approved targeted and immunotherapies outside the …