Cerebral small vessel disease: neuroimaging markers and clinical implication

X Chen, J Wang, Y Shan, W Cai, S Liu, M Hu, S Liao… - Journal of …, 2019 - Springer
Cerebral small vessel disease (CSVD) is a broad category of cerebrovascular diseases
which primarily affect the perforating arterioles, capillaries and venules with multiple distinct …

A practical approach to the management of cerebral amyloid angiopathy

MG Kozberg, V Perosa, ME Gurol… - … Journal of Stroke, 2021 - journals.sagepub.com
Cerebral amyloid angiopathy is a common small vessel disease in the elderly involving
vascular amyloid-β deposition. Cerebral amyloid angiopathy is one of the leading causes of …

Pathophysiology of lacunar stroke: history's mysteries and modern interpretations

RW Regenhardt, AS Das, R Ohtomo, EH Lo… - Journal of Stroke and …, 2019 - Elsevier
Since the term “lacune” was adopted in the 1800s to describe infarctions from cerebral small
vessels, their underlying pathophysiological basis remained obscure until the 1960s when …

Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau

HH Tsai, YF Chen, RF Yen, YL Lo, KC Yang, JS Jeng… - Brain, 2021 - academic.oup.com
Cerebral small vessel disease is one of the most common causes of cognitive decline and
stroke. While several lines of evidence have established a relationship between …

Differences in lobar microbleed topography in cerebral amyloid angiopathy and hypertensive arteriopathy

PY Kuo, HH Tsai, BC Lee, PT Chiang, CJ Liu… - Scientific Reports, 2024 - nature.com
Lobar cerebral microbleeds are a characteristic neuroimaging finding in cerebral amyloid
angiopathy (CAA) but can also be found in hypertensive arteriolosclerosis. We aimed to …

Advanced neuroimaging to unravel mechanisms of cerebral small vessel diseases

ME Gurol, GJ Biessels, JR Polimeni - Stroke, 2020 - Am Heart Assoc
30 Stroke January 2020 resonance imaging (MRI) also added new lesion types to the list of
the classically accepted cSVD-related pathologies. ICH and CMBs in deep-brain regions …

Superficial cerebellar microbleeds and cerebral amyloid angiopathy: a magnetic resonance imaging/positron emission tomography study

HH Tsai, M Pasi, LK Tsai, YF Chen, YW Chen, SC Tang… - Stroke, 2020 - Am Heart Assoc
Background and Purpose—The differentiation between cerebral amyloid angiopathy (CAA)
and hypertensive small vessel disease in primary intracerebral hemorrhage is mainly based …

Novel therapeutic potentials of taxifolin for amyloid-β-associated neurodegenerative diseases and other diseases: Recent advances and future perspectives

M Tanaka, S Saito, T Inoue, N Satoh-Asahara… - International Journal of …, 2019 - mdpi.com
Amyloid-β (Aβ) has been closely implicated in the pathogenesis of cerebral amyloid
angiopathy (CAA) and Alzheimer's disease (AD), the major causes of dementia. Thus, Aβ …

Advances in cerebral amyloid angiopathy imaging

SJ Chen, HH Tsai, LK Tsai, SC Tang… - Therapeutic …, 2019 - journals.sagepub.com
Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β-amyloid
(Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous …

Cerebral amyloid deposition predicts long‐term cognitive decline in hemorrhagic small vessel disease

YC Tsai, HH Tsai, CJ Liu, SS Lin, YF Chen… - Brain and …, 2023 - Wiley Online Library
Background To investigate the association between cerebral amyloid deposition and long‐
term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and …