Leading the pack: Best practices in comparative canine cancer genomics to inform human oncology
CA London, H Gardner, S Zhao… - Veterinary and …, 2023 - Wiley Online Library
Pet dogs develop spontaneous cancers at a rate estimated to be five times higher than that
of humans, providing a unique opportunity to study disease biology and evaluate novel …
of humans, providing a unique opportunity to study disease biology and evaluate novel …
Cross-species oncogenic signatures of breast cancer in canine mammary tumors
Genomic and precision medicine research has afforded notable advances in human cancer
treatment, yet applicability to other species remains uncertain. Through whole-exome and …
treatment, yet applicability to other species remains uncertain. Through whole-exome and …
Translational oncotargets for immunotherapy: From pet dogs to humans
LA Mestrinho, RR Santos - Advanced Drug Delivery Reviews, 2021 - Elsevier
Preclinical studies in rodent models have been a pivotal role in human clinical research, but
many of them fail in the translational process. Spontaneous tumors in pet dogs have the …
many of them fail in the translational process. Spontaneous tumors in pet dogs have the …
Losartan blocks osteosarcoma-elicited monocyte recruitment, and combined with the kinase inhibitor toceranib, exerts significant clinical benefit in canine metastatic …
Purpose: There is increasing recognition that progress in immuno-oncology could be
accelerated by evaluating immune-based therapies in dogs with spontaneous cancers …
accelerated by evaluating immune-based therapies in dogs with spontaneous cancers …
Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma
S Das, R Idate, DP Regan, JS Fowles, SE Lana… - Communications …, 2021 - nature.com
Abstract Osteosarcoma affects about 2.8% of dogs with cancer, with a one-year survival rate
of approximately 45%. The purpose of this study was to characterize mutation and …
of approximately 45%. The purpose of this study was to characterize mutation and …
Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions
Soft tissue sarcomas (STS) are a heterogenous group of mesenchymal tumors representing
over 50 distinct types with overlapping histological features and non-specific anatomical …
over 50 distinct types with overlapping histological features and non-specific anatomical …
The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations
The characterization of immortalized canine osteosarcoma (OS) cell lines used for research
has historically been based on phenotypic features such as cellular morphology and …
has historically been based on phenotypic features such as cellular morphology and …
[HTML][HTML] Genomic tumor analysis provides clinical guidance for the management of diagnostically challenging cancers in dogs
E Chon, G Wang, D Whitley… - Journal of the …, 2023 - Am Vet Med Assoc
Schematic of steps taken for the use of a genomic assay (SearchLight DNA; Vidium Animal
Health) in identifying and annotating mutations occurring within a tumor. This genomic assay …
Health) in identifying and annotating mutations occurring within a tumor. This genomic assay …
A domestic cat whole exome sequencing resource for trait discovery
AR Rodney, RM Buckley, RS Fulton, C Fronick… - Scientific reports, 2021 - nature.com
Over 94 million domestic cats are susceptible to cancers and other common and rare
diseases. Whole exome sequencing (WES) is a proven strategy to study these disease …
diseases. Whole exome sequencing (WES) is a proven strategy to study these disease …
Pharmacokinetics and tolerability of the dual TORC1/2 inhibitor sapanisertib in combination with the MEK inhibitor trametinib in dogs
Activation of one or both the Ras/MAPK and PI3K/Akt/mTOR signal transduction pathways
are known to mediate oncogenicity of several canine and human cancers, including …
are known to mediate oncogenicity of several canine and human cancers, including …