Sebaceous immunobiology-skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

CC Zouboulis, T Coenye, L He, K Kabashima… - Frontiers in …, 2022 - frontiersin.org
This review presents several aspects of the innovative concept of sebaceous
immunobiology, which summarizes the numerous activities of the sebaceous gland …

Matricellular proteins in the homeostasis, regeneration, and aging of skin

E Raja, MTRDC Clarin, H Yanagisawa - International Journal of …, 2023 - mdpi.com
Matricellular proteins are secreted extracellular proteins that bear no primary structural
functions but play crucial roles in tissue remodeling during development, homeostasis, and …

Spatial transcriptomics reveals molecular cues underlying the site specificity of the adult mouse oral mucosa and its stem cell niches

AC Seubert, M Krafft, S Bopp, M Helal, P Bhandare… - Stem Cell Reports, 2024 - cell.com
The oral cavity is a multifunctional organ composed of structurally heterogeneous mucosal
tissues that remain poorly characterized. Oral mucosal tissues are highly stratified and …

Skin single-cell transcriptomics reveals a core of sebaceous gland-relevant genes shared by mice and humans

T Thalheim, MR Schneider - BMC genomics, 2024 - Springer
Background Single-cell RNA sequencing (scRNA-seq) has been widely applied to dissect
cellular heterogeneity in normal and diseased skin. Sebaceous glands, essential skin …

The role of cell–cell and cell–matrix junctional complexes in sebaceous gland homeostasis and differentiation

A Yaba, T Thalheim, MR Schneider - Cell Communication and Signaling, 2024 - Springer
Sebaceous glands (SG) are essential for maintaining skin integrity, as their lipid-rich
secretion (sebum) lubricates and protects the epidermis and hairs. In addition, these glands …

Neutral evolution of snoRNA Host Gene long non-coding RNA affects cell fate control

MV Rudan, KH Sipilä, C Philippeos… - The EMBO …, 2024 - pmc.ncbi.nlm.nih.gov
A fundamental challenge in molecular biology is to understand how evolving genomes can
acquire new functions. Actively transcribed, non-coding parts of the genome provide a …

ECM and epithelial stem cells: the scaffold of destiny

S Estrach, CM Vivier, CC Féral - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Adult stem cells play a critical role in maintaining tissue homeostasis and promoting
longevity. The intricate organization and presence of common markers among adult …

Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice

S Talvi, J Jokinen, K Sipilä, P Rappu, FP Zhang… - Iscience, 2024 - cell.com
Summary Embigin (Gp70), a receptor for fibronectin and an ancillary protein for
monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland …

Neutral evolution of snoRNA Host Gene long non-coding RNA affects cell fate control

M Vietri Rudan, KH Sipilä, C Philippeos… - The EMBO …, 2024 - embopress.org
A fundamental challenge in molecular biology is to understand how evolving genomes can
acquire new functions. Actively transcribed, non-coding parts of the genome provide a …

Embigin Is Highly Expressed on CD4+ and CD8+ T Cells but Is Dispensable for Several T Cell Effector Responses

H Yang, N Iwanaga, AR Katz, AR Ridley… - …, 2024 - journals.aai.org
T cell immunity, including CD4+ and CD8+ T cell immunity, is critical to host immune
responses to infection. Transcriptomic analyses of both CD4+ and CD8+ T cells of C57BL/6 …