Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer
processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion …

Extracellular vesicles (EVs) are a heterogeneous group of membrane-limited vesicles and
multi-signal messengers loaded with biomolecules. Exosomes and ectosomes are two …

Proteasomes, the primary mediators of ubiquitin–protein conjugate degradation, are
regulated through complex and poorly understood mechanisms. Here we show that USP14 …

Due to its multiple features, including the ability to orchestrate remote communication
between different tissues, the exosomes are the extracellular vesicles arousing the highest …

The past two years have seen an explosion in the structural understanding of the endosomal
sorting complex required for transport (ESCRT) machinery that facilitates the trafficking of …

TGF-β-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key
modulator of the inducible transcription factors NF-κB and AP-1 and, therefore, plays a …

Extracellular vesicles (EVs) are nanoscale extracellular vesicles derived from endocytosis
that are crucial to intercellular communication. EVs possess natural biocompatibility and …

Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from
the outer surface to the inner compartments of the cell. Long considered as a passive means …

Gynecologic cancer is a group of any malignancies affecting reproductive tissues and
organs of women, including ovaries, uterine, cervix, vagina, vulva, and endometrium …

Transforming growth factor-β (TGF-β) is a multifunctional cytokine of key importance for
controlling embryogenesis and tissue homeostasis. How TGF-β signals are attenuated and …