The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …

Protective immune responses against respiratory pathogens, such as severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the …

Vγ9Vδ2 T cells are the largest population of γδ T cells in adults and can play important roles
in providing effective immunity against cancer and infection. Many studies have suggested …

Mechanisms of tissue-specific gene expression regulation via 3D genome organization are
poorly understood. Here we uncover the regulatory chromatin network of developing T cells …

Zinc is well‐known to have a central role in human inflammation and immunity and is itself
an anti‐inflammatory and antiviral agent. Despite its massively documented role in such …

Abstract CD4+ and CD8+ double-positive (DP) thymocytes play a crucial role in T cell
development in the thymus. DP cells rearrange the T cell receptor gene Tcra to generate T …

Invariant natural killer T cells (iNKT cells) differentiate into thymic and peripheral NKT1,
NKT2 and NKT17 subsets. Here we use RNA-seq and ATAC-seq analyses and show iNKT …

Summary N 6-methyladenosine (m 6 A) methyltransferase Mettl3 is involved in conventional
T cell immunity; however, its role in innate immune cells remains largely unknown. Here, we …

TCRαβ+ CD8αα+ intraepithelial lymphocytes (CD8αα+ αβ IELs) are a specialized subset of
T cells in the gut epithelium that develop from thymic agonist selected IEL precursors …

Mucosal-associated invariant T (MAIT) cells recognize microbial riboflavin metabolites
presented by MR1 and play role in immune responses to microbial infections and tumors …