Discovery and clinical translation of novel glaucoma biomarkers

G Beykin, AM Norcia, VJ Srinivasan, A Dubra… - Progress in Retinal and …, 2021 - Elsevier
Glaucoma and other optic neuropathies are characterized by progressive dysfunction and
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …

[HTML][HTML] Topical glaucoma medications–clinical implications for the ocular surface

F Fineide, N Lagali, MY Adil, R Arita, M Kolko, J Vehof… - The ocular …, 2022 - Elsevier
Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to
reduce intraocular pressure remains the mainstay treatment. These eye drops frequently …

Tear and aqueous humour cytokine profile in primary open‐angle glaucoma

B Burgos‐Blasco, B Vidal‐Villegas… - Acta …, 2020 - Wiley Online Library
Purpose To evaluate the concentrations of pro‐inflammatory cytokines in tear and aqueous
humour of patients with primary open‐angle glaucoma (POAG), relative to healthy controls …

Candidate glaucoma biomarkers: From proteins to metabolites, and the pitfalls to clinical applications

AFV Cueto, L Álvarez, M García, A Álvarez-Barrios… - Biology, 2021 - mdpi.com
Simple Summary Glaucoma is a devastating eye disease causing progressive vision loss
and consequent irreversible blindness. The global prevalence of glaucoma is estimated at …

Biomarkers in tears and ocular surface: a window for neurodegenerative diseases

M Roda, C Ciavarella, G Giannaccare… - Eye & Contact …, 2020 - journals.lww.com
Objectives: The purpose of this review is to briefly outline current scientific evidence on the
potential role of tear analysis and ocular surface evaluation in diagnosis and monitoring of …

Clinical tear fluid proteomics—a novel tool in glaucoma research

J Nättinen, U Aapola, P Nukareddy… - International Journal of …, 2022 - mdpi.com
Tear fluid forms the outermost layer of the ocular surface and its characteristics and
composition have been connected to various ocular surface diseases. As tear proteomics …

[HTML][HTML] Roles of matrix metalloproteinases in the cornea: A special focus on macular corneal dystrophy

SG Kaya, S Inanc-Surer, G Cakan-Akdogan… - Medicine in Drug …, 2021 - Elsevier
Matrix metalloproteinases (MMPs) are endopeptidases that are responsible for the
degradation of several components of the extracellular matrix (ECM) and some non-ECM …

Shedding Valuable Tears: Tear Fluid as a Promising Source of Disease Biomarkers

IS Vavilina, AA Shpak, TA Druzhkova, AB Guekht… - Neurochemical …, 2023 - Springer
The simplicity of collecting and evaluating tear fluid (TF) can potentially provide a convenient
non-invasive diagnostic tool that easily fits into a personalized approach to medicine based …

Changes in tear proteomic profile in ocular diseases

M Winiarczyk, K Biela, K Michalak… - International Journal of …, 2022 - mdpi.com
The search for proteomic biomarkers in ocular disease is one of the most important research
directions in recent years. Reliable biomarkers can be an immense adjuvant for both …

Effect of topical prostaglandin F2α analogs on selected oxidative stress parameters in the tear film

L Sedlak, M Zych, W Wojnar… - Medicina, 2019 - mdpi.com
Background and Objectives: Topically administered antiglaucoma medications, especially
those containing benzalkonium chloride (BAC), may cause local adverse effects and …