Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …

Pancreatitis is caused by inflammatory injury to the exocrine pancreas, from which both
humans and animal models appear to recover via regeneration of digestive enzyme …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers owing to a
number of characteristics including difficulty in establishing early diagnosis and the absence …

Differentiated cells can re-enter the cell cycle to repair tissue damage via a series of discrete
morphological and molecular stages coordinated by the cellular energetics regulator …

BACKGROUND & AIMS: Fibroblast growth factor 21 (FGF21) acts as a hormonal regulator
during fasting and is involved in lipid metabolism. Fgf21 gene expression is regulated by …

BACKGROUND & AIMS: Invasive pancreatic ductal adenocarcinoma is thought to originate
from duct-like lesions called pancreatic intraepithelial neoplasia (PanIN). PanINs progress …

OBJECTIVE Clinical reports link use of the glucagon-like peptide-1 receptor (GLP-1R)
agonists exenatide and liraglutide to pancreatitis. However, whether these agents act on the …

Differentiated cells across multiple species and organs can re‐enter the cell cycle to aid in
injury‐induced tissue regeneration by a cellular program called paligenosis. Here, we show …

Background. Danshen (Salvia miltiorrhiza Bunge) and its main active component
Tanshinone IIA (TSA) are clinically used in China. However, the effects of TSA on acute …

Little is known about how differentiating cells reorganize their cellular structure to perform
specialized physiological functions. MIST1, an evolutionarily conserved transcription factor …