Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

The relationship between the age-associated decline in mitochondrial function and its effect
on skeletal muscle physiology and function remain unclear. In the current study, we …

To characterize the proteomic signature of chronological age, 1,301 proteins were
measured in plasma using the SOMAscan assay (SomaLogic, Boulder, CO, USA) in a …

Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …

Observational data have shown that some cancer survivors develop chronic conditions like
frailty, sarcopenia, cardiac dysfunction, and mild cognitive impairment earlier and/or at a …

Abstract Changes in old age that contribute to the complex issue of an increased metabolic
cost of walking (mass-specific energy cost per unit distance traveled) in older adults appear …

Magnetic resonance imaging (MRI) is a valuable tool for evaluating musculoskeletal disease
as it offers a range of image contrasts that are sensitive to underlying tissue biochemical …

Background The concept of mitochondrial dysfunction in ageing muscle is highly
controversial. In addition, emerging evidence suggests that reduced muscle oxidative …

Background Muscle mitochondrial dysfunction is associated with poor mobility in aging.
Whether mitochondrial dysfunction predicts subsequent mobility decline is unknown …