Nonsteroidal anti-inflammatory drugs and the kidney
WH Hörl - Pharmaceuticals, 2010 - mdpi.com
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of
cyclooxygenase (COX). Renal side effects (eg, kidney function, fluid and urinary electrolyte …
cyclooxygenase (COX). Renal side effects (eg, kidney function, fluid and urinary electrolyte …
Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs
B KuKanich, T Bidgood, O Knesl - Veterinary anaesthesia and analgesia, 2012 - Elsevier
Objectives To discuss the clinical pharmacology of currently licensed veterinary NSAIDs and
to review gastrointestinal and renal adverse effects as well as drug-drug interactions that …
to review gastrointestinal and renal adverse effects as well as drug-drug interactions that …
Celecoxib pathways: pharmacokinetics and pharmacodynamics
Background Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) with anti-
inflammatory, analgestic, and antipyretic properties. It is approved for the treatment of …
inflammatory, analgestic, and antipyretic properties. It is approved for the treatment of …
Potassium channels in peripheral pain pathways: expression, function and therapeutic potential
X Du, N Gamper - Current neuropharmacology, 2013 - ingentaconnect.com
Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …
Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter
KCNQ gene expression was previously shown in various rodent blood vessels, where the
products of KCNQ4 and KCNQ5, Kv7. 4 and Kv7. 5 potassium channel subunits …
products of KCNQ4 and KCNQ5, Kv7. 4 and Kv7. 5 potassium channel subunits …
Expression and function of the K+ channel KCNQ genes in human arteries
BACKGROUND AND PURPOSE KCNQ‐encoded voltage‐gated potassium channels (Kv7)
have recently been identified as important anti‐constrictor elements in rodent blood vessels …
have recently been identified as important anti‐constrictor elements in rodent blood vessels …
The effects of pain and analgesic medications on blood pressure
G Rivasi, S Menale, G Turrin, A Coscarelli… - Current Hypertension …, 2022 - Springer
Abstract Purpose of Review To review the blood pressure (BP) effects of pain and analgesic
medications and to help interpret BP changes in people suffering from acute or chronic pain …
medications and to help interpret BP changes in people suffering from acute or chronic pain …
M‐type K+ channels in peripheral nociceptive pathways
X Du, H Gao, D Jaffe, H Zhang… - British journal of …, 2018 - Wiley Online Library
Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and
controlled by a complement of ion channels it expresses, in order to understand and treat …
controlled by a complement of ion channels it expresses, in order to understand and treat …
[HTML][HTML] Optimization of pyrazolo [1, 5-a] pyrimidine based compounds with pyridine scaffold: Synthesis, biological evaluation and molecular modeling study
Background Pyrazolopyrimidine heterocycle and its isosteres represent the main scaffold for
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …
Novel treatment strategies for smooth muscle disorders: Targeting Kv7 potassium channels
JM Haick, KL Byron - Pharmacology & therapeutics, 2016 - Elsevier
Smooth muscle cells provide crucial contractile functions in visceral, vascular, and lung
tissues. The contractile state of smooth muscle is largely determined by their electrical …
tissues. The contractile state of smooth muscle is largely determined by their electrical …