This chapter reviews how allosteric (heterotrophic) effectors and natural mutations impact
hemoglobin (Hb) primary physiological function of oxygen binding and transport. First, an …

Allostery is the process by which biological macromolecules (mostly proteins) transmit the
effect of binding at one site to another, often distal, functional site, allowing for regulation of …

A survey of the literature is presented that provides an analysis of the optical properties of
human skin, with particular regard to their applications in medicine. Included is a description …

Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

We have developed a deep-scale proteome and phosphoproteome database from 44
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …

Function in biological systems is exquisitely dependent on spatial and temporal changes in
biomacromolecules. Innumerable biological processes ultimately rely on transduction of …

The biomolecular conformational changes often associated with allostery are, by definition,
dynamic processes. Recent publications have disclosed the role of pre-existing equilibria of …

Biotechnology has revolutionized science and health care by providing new biomolecules
with biological and medical applications. However, the low stability of several life-saving …

Nanomedicine is a discipline that applies nanoscience and nanotechnology principles to the
prevention, diagnosis, and treatment of human diseases. Self-assembly of molecular …

The use of residual dipolar couplings (RDCs) in the analysis of biomolecular structure and
dynamics has expanded rapidly since its potential as a source of structural information on …