Transition metal catalysis is of utmost importance for the development of sustainable
processes in academia and industry. The activity and selectivity of metal complexes are …

Discovered as organometallic curiosities in the 1970s, carbene radicals have become a
staple in modern-day homogeneous catalysis. Carbene radicals exhibit nucleophilic radical …

Methyl groups are well understood to play a critical role in pharmaceutical molecules,
especially those bearing saturated heterocyclic cores. Accordingly, methods that install …

Bimolecular homolytic substitution (SH2) is an open-shell mechanism that is implicated
across a host of biochemical alkylation pathways. Surprisingly, however, this radical …

Cyclopropanes bearing contiguous all-carbon quaternary centers continue to attract
attention due to their bioactivities. However, methods to obtain cyclopropanes with …

Aromatic tertiary amines are one of the most important classes of organic compounds in
organic chemistry and drug discovery. It is difficult to efficiently construct tertiary amines from …

Stereoselective cyclopropanation reaction of alkenes is usually achieved by metal
complexes via singlet‐metal‐carbene intermediates. However, previous transition‐metal …

Since Friedrich Wöhler's groundbreaking synthesis of urea in 1828, organic synthesis over
the past two centuries has predominantly relied on the exploration and utilization of …

Enzymes are the core for biological transformations in nature. Their structures and functions
have drawn enormous attention from biologists as well as chemists since last century. The …

Asymmetric radical bicyclization processes have been developed via metalloradical
catalysis (MRC) to stereoselectively construct chiral chromanones and chromanes bearing …