Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain
HC Feldman, E Merlini, C Guijas… - Proceedings of the …, 2022 - National Acad Sciences
The nicotinamide adenine dinucleotide hydrolase (NADase) sterile alpha toll/interleukin
receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon …
receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon …
SARM1 is a multi-functional NAD (P) ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites
Summary SARM1 is an NAD (P) glycohydrolase and TLR adapter with an essential,
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders
SARM1, a protein with critical NADase activity, is a central executioner in a conserved
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
[HTML][HTML] NMN: the NAD precursor at the intersection between axon degeneration and anti-ageing therapies
The past 20 years of research on axon degeneration has revealed fine details on how NAD
biology controls axonal survival. Extensive data demonstrate that the NAD precursor NMN …
biology controls axonal survival. Extensive data demonstrate that the NAD precursor NMN …
Sarm1-dependent axon degeneration: Nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities
Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
Multifaceted roles of SARM1 in axon degeneration and signaling
TJ Waller, CA Collins - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell–neuron cocultures
C Mutschler, SV Fazal, N Schumacher… - Journal of Cell …, 2023 - journals.biologists.com
Myelinating Schwann cell (SC)–dorsal root ganglion (DRG) neuron cocultures are an
important technique for understanding cell–cell signalling and interactions during peripheral …
important technique for understanding cell–cell signalling and interactions during peripheral …
Augustus Waller's foresight realized: SARM1 in peripheral neuropathies
S Geisler - Current Opinion in Neurobiology, 2024 - Elsevier
Peripheral neuropathy is a common neurodegenerative condition characterized by
numbness, tingling, pain, and weakness that frequently starts in the distal limbs. Arising from …
numbness, tingling, pain, and weakness that frequently starts in the distal limbs. Arising from …