Escherichia coli is a paradigm for a versatile bacterial species which comprises harmless
commensal as well as different pathogenic variants with the ability to either cause intestinal …

At the initial stage of drug discovery, identifying novel targets with maximal efficacy and
minimal side effects can improve the success rate and portfolio value of drug discovery …

The combination of high-density transposon-mediated mutagenesis and high-throughput
sequencing has led to significant advancements in research on essential genes, resulting in …

De novo mutation plays an important role in autism spectrum disorders (ASDs). Notably,
pathogenic copy number variants (CNVs) are characterized by high mutation rates. We …

The protein–protein interaction (PPI) network is crucial for cellular information processing
and decision-making. With suitable inputs, PPI networks drive the cells to diverse functional …

OGEE is an Online GEne Essentiality database. To enhance our understanding of the
essentiality of genes, in OGEE we collected experimentally tested essential and non …

OGEE is an Online GEne Essentiality database. Gene essentiality is not a static and binary
property, rather a context-dependent and evolvable property in all forms of life. In OGEE we …

Motivation To complement experimental efforts, machine learning-based computational
methods are playing an increasingly important role to predict human–virus protein–protein …

High-throughput analysis of genome-wide random transposon mutant libraries is a powerful
tool for (conditional) essential gene discovery. Recently, several next-generation …

Various disciplines are trying to solve one of the most noteworthy queries and broadly used
concepts in biology, essentiality. Centrality is a primary index and a promising method for …