Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble
plasma high-density lipoproteins (HDLs), which are a compositionally and structurally …

Multiple sclerosis is clinically characterized by relapses and remissions (relapsing-remitting
multiple sclerosis) that over time may evolve to a progressive course (secondary progressive …

Background The use of lipid-lowering drugs is still highly controversial in patients with
amyotrophic lateral sclerosis (ALS). We performed a drug-target Mendelian randomization …

Apolipoprotein B (APOB), a receptor-binding protein present in cholesterol-rich lipoproteins,
has been implicated in Alzheimer's disease (AD). High levels of APOB-containing low …

Observational studies have faced challenges in identifying replicable causes for
amyotrophic lateral sclerosis (ALS). To address this, we employed an unbiased and data …

Amyotrophic lateral sclerosis (ALS) is a fatal, currently incurable neurodegenerative disease
that progressively affects the upper motor neurons in the brain and lower motor neurons in …

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating
neurodegenerative disorder primarily affecting motor neurons in the central nervous system …

The current knowledge on pathogenic mechanisms in amyotrophic lateral sclerosis (ALS)
has widely been derived from studies with cell and animal models bearing ALS-linked …

Mice are the most commonly used preclinical animal model, but protein analytics of murine
cerebrospinal fluid (CSF) remains challenging because of low CSF volume (often< 10 …

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor
neurons and premature death. The limited understanding of the mechanisms underlying …