Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: a review
MP Girard, S Osmanov, OM Assossou, MP Kieny - Vaccine, 2011 - Elsevier
The development of a safe, effective and globally affordable HIV vaccine offers the best
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
SG Hansen, JC Ford, MS Lewis, AB Ventura… - Nature, 2011 - nature.com
The acquired immunodeficiency syndrome (AIDS)-causing lentiviruses human
immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) effectively evade …
immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) effectively evade …
DNA vaccines against cancer come of age
FK Stevenson, CH Ottensmeier, J Rice - Current opinion in immunology, 2010 - Elsevier
Genetic technology allows construction of DNA vaccines encoding selected tumor antigens
together with molecules to direct and amplify the desired effector pathways. Their enormous …
together with molecules to direct and amplify the desired effector pathways. Their enormous …
Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery
SA Kalams, SD Parker, M Elizaga… - The Journal of …, 2013 - academic.oup.com
Background. DNA vaccines have been very poorly immunogenic in humans but have been
an effective priming modality in prime-boost regimens. Methods to increase the …
an effective priming modality in prime-boost regimens. Methods to increase the …
Co-immunization of DNA and protein in the same anatomical sites induces superior protective immune responses against SHIV challenge
We compare immunogenicity and protective efficacy of an HIV vaccine comprised of env and
gag DNA and Env (Envelope) proteins by co-administration of the vaccine components in …
gag DNA and Env (Envelope) proteins by co-administration of the vaccine components in …
Tolerability of intramuscular and intradermal delivery by CELLECTRA® adaptive constant current electroporation device in healthy volunteers
MC Diehl, JC Lee, SE Daniels, P Tebas… - Human vaccines & …, 2013 - Taylor & Francis
DNA vaccines are being developed as a potentially safe and effective immunization
platform. However, translation of DNA vaccines into a clinical setting has produced results …
platform. However, translation of DNA vaccines into a clinical setting has produced results …
Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques
Adjuvant effects on innate as well as adaptive immunity may be critical for inducing
protection against mucosal HIV and simian immunodeficiency virus (SIV) exposure. We …
protection against mucosal HIV and simian immunodeficiency virus (SIV) exposure. We …
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques
Intramuscular injection of macaques with an IL-12 expression plasmid (0.1 or 0.4 mg
DNA/animal) optimized for high level of expression and delivered using in vivo …
DNA/animal) optimized for high level of expression and delivered using in vivo …
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge
We have previously shown that macaques vaccinated with DNA vectors expressing
SIVmac239 antigens developed potent immune responses able to reduce viremia upon high …
SIVmac239 antigens developed potent immune responses able to reduce viremia upon high …
[HTML][HTML] HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques
J Li, A Valentin, V Kulkarni, M Rosati, RK Beach… - Vaccine, 2013 - Elsevier
Abstract Vaccination with HIV/SIV DNAs elicits potent T-cell responses. To improve humoral
immune responses, we combined DNA and protein in a co-immunization protocol using in …
immune responses, we combined DNA and protein in a co-immunization protocol using in …