Novel insight into astrocyte-mediated gliotransmission modulates the synaptic plasticity in major depressive disorder

L Lei, YF Wang, CY Chen, YT Wang, Y Zhang - Life Sciences, 2024 - Elsevier
Major depressive disorder (MDD) is a form of glial cell-based synaptic dysfunction disease
in which glial cells interact closely with neuronal synapses and perform synaptic information …

Understanding current experimental models of glioblastoma-brain microenvironment interactions

N Yadav, BW Purow - Journal of Neuro-oncology, 2024 - Springer
Glioblastoma (GBM) is a common and devastating primary brain tumor, with median survival
of 16–18 months after diagnosis in the setting of substantial resistance to standard-of-care …

Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex

J Gonçalves‐Ribeiro, OK Savchak, S Costa‐Pinto… - Glia, 2024 - Wiley Online Library
The medial prefrontal cortex (mPFC) is involved in cognitive functions such as working
memory. Astrocytic cannabinoid type 1 receptor (CB1R) induces cytosolic calcium (Ca2+) …

The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes

C García‐Rodríguez, Y Duarte… - Journal of …, 2024 - Wiley Online Library
Glial cells play relevant roles in neuroinflammation caused by epilepsy. Elevated
hemichannel (HC) activity formed by connexins (Cxs) or pannexin1 (Panx1) largely explains …

Systemic corticosterone enhances fear memory extinction in rats: Involvement of the infralimbic medial prefrontal cortex GABAA and GABAB receptors

S Omoumi, A Rashidy‐Pour, SA Seyedinia… - Brain and …, 2024 - Wiley Online Library
Purpose The infralimbic (IL) subregion of the medial prefrontal cortex (mPFC) regulates the
extinction of conditioned fear memory. Glucocorticoid and gamma‐aminobutyric acid …