Formulation, structure, and applications of therapeutic and amino acid-based deep eutectic solvents: An overview

MS Rahman, R Roy, B Jadhav, MN Hossain… - Journal of Molecular …, 2021 - Elsevier
In the design of greener chemicals, deep eutectic solvents (DESs) are considered as one of
the most versatile alternative media with widespread applications. DESs have the …

Oxindole: A chemical prism carrying plethora of therapeutic benefits

M Kaur, M Singh, N Chadha, O Silakari - European Journal of Medicinal …, 2016 - Elsevier
Oxindole has emerged as a valuable scaffold in medicinal chemistry possessing diverse
range of pharmacological activities. Its value has further been increased by its natural …

Bis-and trisindolylmethanes (BIMs and TIMs)

M Shiri, MA Zolfigol, HG Kruger… - Chemical …, 2010 - ACS Publications
The indole ring system is present in many natural products, pharmaceuticals,
agrochemicals, and other compounds of importance. 1–8 The indole unit forms the basis for …

Recent advances in diversity oriented synthesis through isatin‐based multicomponent reactions

Y Liu, H Wang, J Wan - Asian Journal of Organic Chemistry, 2013 - Wiley Online Library
Isatins are well‐known carbonyl electrophiles which allow a vast number of reactions
initiated by nucleophilic attack on the C3 carbonyl group when used as starting materials …

Molecular iodine-catalyzed multicomponent reactions: an efficient catalyst for organic synthesis

YM Ren, C Cai, RC Yang - RSC advances, 2013 - pubs.rsc.org
The multicomponent reactions (MCRs) consist of two or more synthetic steps which are
carried out without isolation of any intermediate thus reducing time, saving money, energy …

Effective synthesis and biological evaluation of natural and designed bis (indolyl) methanes via taurine-catalyzed green approach

KA Chavan, M Shukla, ANS Chauhan, S Maji… - ACS …, 2022 - ACS Publications
An ecofriendly, inexpensive, and efficient route for synthesizing 3, 3′-bis (indolyl) methanes
(BIMs) and their derivatives was carried out by an electrophilic substitution reaction of indole …

Lambert salt-initiated development of Friedel–crafts reaction on isatin to access distinct derivatives of oxindoles

J Khan, A Tyagi, N Yadav, R Mahato… - The Journal of Organic …, 2021 - ACS Publications
Herein, a mild metal-free and efficacious route for the synthesis of biologically important 3-
aryl oxindole derivatives is described. Using Lambert salt-initiated hydroarylation of isatin, a …

Synthesis of 3, 3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activity

A Kamal, YVV Srikanth, MNA Khan, TB Shaik… - Bioorganic & medicinal …, 2010 - Elsevier
A simple and highly efficient method has been developed for the synthesis of 3, 3-diindolyl
oxyindoles by the reaction of indoles with isatin or 5-fluoro isatin using a catalytic amount …

Substrate-controlled regioselective arylations of 2-indolylmethanols with indoles: synthesis of bis (indolyl) methane and 3, 3′-bisindole derivatives

YY He, XX Sun, GH Li, GJ Mei, F Shi - The Journal of Organic …, 2017 - ACS Publications
A substrate-controlled regioselective arylation of 2-indolylmethanols with indoles has been
established, which efficiently afforded bis (indolyl) methane and 3, 3′-bisindole derivatives …

Design for carbon–carbon bond forming reactions under ambient conditions

G Brahmachari - RSC advances, 2016 - pubs.rsc.org
The carbon–carbon (C–C) bond forms the 'backbone'of nearly every organic molecule, and
lies at the heart of the chemical sciences! This transformation has always been one of the …