A comprehensive account on recent progress in pharmacological activities of benzimidazole derivatives

SR Brishty, MJ Hossain, MU Khandaker… - Frontiers in …, 2021 - frontiersin.org
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …

Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

J Akhtar, AA Khan, Z Ali, R Haider, MS Yar - European journal of medicinal …, 2017 - Elsevier
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

[HTML][HTML] Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

YT Lee, YJ Tan, CE Oon - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Cancer is the second leading cause of mortality globally which remains a continuing threat
to human health today. Drug insensitivity and resistance are critical hurdles in cancer …

Recent advances (2015–2016) in anticancer hybrids

N Kerru, P Singh, N Koorbanally, R Raj… - European journal of …, 2017 - Elsevier
In spite of the development of a large number of novel anticancer drugs over the years,
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …

Two sandwich-type uranyl-containing polytungstates catalyze aerobic synthesis of benzimidazoles

YF Liu, QL Hu, XJ Chen, K Li, P Luo, GP Yang - Rare Metals, 2024 - Springer
Diversified synthetic strategies are extremely important for the structural diversity of uranium-
containing polyoxometalates (U-POMs) and their functional expansion. Herein, two …

A review on the green synthesis of benzimidazole derivatives and their pharmacological activities

M Nardi, NCH Cano, S Simeonov, R Bence, A Kurutos… - Catalysts, 2023 - mdpi.com
Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic
agents, eg, antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of …

Benzimidazole scaffold as anticancer agent: synthetic approaches and structure–activity relationship

N Shrivastava, MJ Naim, MJ Alam, F Nawaz… - Archiv der …, 2017 - Wiley Online Library
Cancer, also known as malignant neoplasm, is a dreadful disease which involves abnormal
cell growth having the potential to invade or spread to other parts of the body …

1, 3, 5-Triazines: A promising scaffold for anticancer drugs development

S Cascioferro, B Parrino, V Spanò, A Carbone… - European journal of …, 2017 - Elsevier
This review covering literature reports from the beginning of this century to 2016 describes
the synthetic pathways, the antitumor activity, the structure-activity relationship and …

Recent advances in the biological activity of s-triazine core compounds

D Maliszewski, D Drozdowska - Pharmaceuticals, 2022 - mdpi.com
An effective strategy for successful chemotherapy relies on creating compounds with high
selectivity against cancer cells compared to normal cells and relatively low cytotoxicity. One …

Triazine as a promising scaffold for its versatile biological behavior

P Singla, V Luxami, K Paul - European journal of medicinal chemistry, 2015 - Elsevier
Among all heterocycles, the triazine scaffold occupies a prominent position, possessing a
broad range of biological activities. Triazine is found in many potent biologically active …