Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Hyperphosphorylation of the C-terminal domain (CTD) of the RPB1 subunit of human RNA
polymerase (Pol) II is essential for transcriptional elongation and mRNA processing,–. The …

The increasing population will challenge healthcare, particularly because the worldwide
population has never been older. Therapeutic solutions to age-related disease will be …

Down syndrome is the main cause of intellectual disabilities with a large set of comorbidities
from developmental origins but also that appeared across life span. Investigation of the …

Huntington's disease (HD) is a progressive neurodegenerative disorder that is characterized
by motor, cognitive, and psychiatric problems. It is caused by a polyglutamine expansion in …

Huntington's disease (HD) is caused by an expansion of a CAG repeat in the gene that
encodes the huntingtin protein (HTT). The exact function of HTT is still not fully understood …

The hypothalamus has a vital role in controlling food intake and energy homeostasis; its
activity is modulated by neuropeptides and endocrine factors. Mesencephalic astrocyte …

Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with
huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion …

Binding of motor proteins to cellular cargoes is regulated by adaptor proteins. HAP1 and
GRIP1 are kinesin-1 adaptors that have been implicated individually in the transport of …