PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells

A Maharati, M Moghbeli - Cell Communication and Signaling, 2023 - Springer
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are
considered as a global health challenge. Despite many progresses in therapeutic methods …

PI3K/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cells

ZN Navaei, G Khalili-Tanha, AS Zangouei… - Oncology …, 2022 - pmc.ncbi.nlm.nih.gov
Chemotherapy is one of the main therapeutic modalities for cancer patients. Cisplatin
(CDDP), as one of the first-line drugs, is of great importance in the chemotherapy of various …

Long non-coding RNAs as the critical regulators of PI3K/AKT, TGF-β, and MAPK signaling pathways during breast tumor progression

A Maharati, M Moghbeli - Journal of translational medicine, 2023 - Springer
Breast cancer (BC) as one of the most common causes of human deaths among women, is
always considered one of the global health challenges. Despite various advances in …

Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance

H Elimam, NAA Alhamshry, A Hatawsh, N Elfar… - Naunyn-Schmiedeberg's …, 2024 - Springer
Gallbladder cancer (GBC) is an aggressive and lethal malignancy with a poor prognosis.
Long noncoding RNAs (lncRNAs) and natural products have emerged as key orchestrators …

Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid

M Karami Fath, J Azami, N Jaafari… - Cellular & Molecular …, 2022 - Springer
Exosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising
heterogeneous contents such as nucleic acids, proteins, and DNA. These bi-layered …

LncRNA-miRNA interaction is involved in colorectal cancer pathogenesis by modulating diverse signaling pathways

SH Alshahrani, ZSM Al-Hadeithi, SG Almalki… - … -Research and Practice, 2023 - Elsevier
LncRNAs function as molecular sponges for miRNAs to control their availability for targeting
mRNA molecules. This procedure indirectly regulates the expression of cancer-related …

Circular RNAs as the pivotal regulators of epithelial-mesenchymal transition in gastrointestinal tumor cells

RA Mahmoudian, I Akhlaghipour, M Lotfi… - … -Research and Practice, 2023 - Elsevier
Gastrointestinal (GI) cancers, as the most common human malignancies are always
considered one of the most important health challenges in the world. Late diagnosis in …

A review on the role of long non-coding RNA and microRNA network in clear cell renal cell carcinoma and its tumor microenvironment

Q Zhang, H Ren, L Ge, W Zhang, F Song… - Cancer Cell …, 2023 - Springer
Renal cell carcinoma (RCC) is the second lethal urogenital malignancy with the increasing
incidence and mortality in the world. Clear cell renal cell carcinoma (ccRCC) is one major …

The regulatory functions and the mechanisms of long non-coding RNAs in cervical cancer

Q Yang, A Al-Hendy - Cells, 2022 - mdpi.com
Cervical cancer is one of the leading causes of death in gynecology cancer worldwide. High-
risk human papillomaviruses (HPVs) are the major etiological agents for cervical cancer …

MicroRNAs as the pivotal regulators of cisplatin resistance in head and neck cancers

F Tolue Ghasaban, A Maharati, AS Zangouei… - Cancer cell …, 2023 - Springer
Although, there is a high rate of good prognosis in early stage head and neck tumors, about
half of these tumors are detected in advanced stages with poor prognosis. A combination of …