Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …

The stem cell markers octamer-binding transcription factor 4, sex-determining region Y-box
2, NANOG, Kruppel-like factor 4 and c-MYC are key factors in inducing pluripotency in …

Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity
and the regulation of gene expression. Here, we identify an evolutionarily conserved …

Alternative splicing of precursor mRNA is an important mechanism that increases
transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA …

Although somatic cell activation of the embryonic stem cell (ESC) pluripotency factor OCT4
has been reported, this previous work has been controversial and has not demonstrated a …

The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and
OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by …

The generation of research-quality, clinically relevant cell types in vitro from human
pluripotent stem cells requires a detailed understanding of the equivalent human cell types …

Guo Y, Liu S, Wang P, Zhao S, Wang F, Bing L, Zhang Y, Ling E‐A, Gao J & Hao A (2011)
Histopathology59, 763–775 Expression profile of embryonic stem cell‐associated genes …

OCT4 was discovered more than two decades ago as a transcription factor specific to early
embryonic development. Early studies with OCT4 were descriptive and looked at …

Octamer-binding transcription factor 4 (Oct4), a homeodomain transcription factor, is well
established as a master factor controlling the self-renewal and pluripotency of pluripotent …