Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Plant antimicrobial peptides (AMPs) are a component of barrier defense system of plants.
They have been isolated from roots, seeds, flowers, stems, and leaves of a wide variety of …

Bioactive peptides have potential as drug leads, but turning them into drugs is a challenge
because of their typically poor metabolic stability. Molecular grafting is one approach to …

Highlights•Cyclic peptides are ideal inhibitors of protein–protein interactions (PPIs), due to
low immunogenicity and large surface area.•Peptide libraries are excellent tools to screen …

Covering: up to July 2008 Ribosomally synthesized bacterial natural products rival the
nonribosomal peptides in their structural and functional diversity. The last decade has seen …

Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …

Highlights•Cyclotides are ultra-stable and tolerant to sequence substitutions in all
loops.•Sequences grafted into a cyclotide scaffold are stabilized and generally maintain …

Cyclotides, a large family of cyclic peptides from plants, have a broad range of biological
activities, including insecticidal, cytotoxic, and anti-HIV activities. In all of these activities, cell …

Cyclotides are plant derived mini-proteins with compact folded structures and exceptional
stability. Their stability derives from a head-to-tail cyclized backbone coupled with a cystine …