The biggest compartment of the musculoskeletal system is the tendons and ligaments. In
particular, tendons are dense tissues connecting muscle to bone that are critical for the …

Combining stem cells with biomaterial scaffolds serves as a promising strategy for
engineering tissues for both in vitro and in vivo applications. This updated review details …

Mimicking the hierarchically anisotropic structure and excellent mechanical properties of
natural tissues, such as tendons and ligaments, using biomaterials is challenging. Despite …

Discectomy procedures alleviate disability caused by intervertebral disc (IVD) herniation, but
do not repair herniation-induced annulus fibrosus (AF) defects. Cell therapy shows promise …

Tendons are unique forms of connective tissue aiming to transmit the mechanical force of
muscle contraction to the bones. Tendon injury may be due to direct trauma or might be …

Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon
healing results in scar tissue formation and fibrosis with suboptimal biomechanical …

Introduction Tendinopathies are common in elite and recreational athletes: traditionally
considered overuse injuries, they involve excessive tensile loading and subsequent …

Tendon and ligament tissues provide stability and mobility crucial for musculoskeletal
function, but are particularly prone to injury. Owing to poor innate healing capacity, the …

Tendon aging is associated with an increasing prevalence of tendon injuries and/or chronic
tendon diseases, such as tendinopathy, which affects approximately 25% of the adult …

The poor healing capacity of tendons is known to worsen in the elderly. During tendon aging
and degeneration, endogenous human tendon stem/progenitor cells (hTSPCs) experience …