Combination therapies are superior to monotherapy for many cancers. This advantage was
historically ascribed to the ability of combinations to address tumor heterogeneity, but …

Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

Increasing knowledge of intertumor heterogeneity, intratumor heterogeneity, and cancer
evolution has improved the understanding of anticancer treatment resistance. A better …

Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer
therapy today. However, evolving resistance to one drug may come at a cost of decreased …

Diffuse gliomas are the most frequent brain tumours, representing 75% of all primary
malignant brain tumours in adults. Because of their locally aggressive behaviour and the fact …

Background Cancer refers to a group of some of the worldwide most diagnosed and
deadliest pathophysiological conditions that conquered researchers' attention for decades …

Lung cancer is the most common cause of cancer-related deaths globally. Genetic
alterations, such as amplifications, mutations and translocations in the fibroblast growth …

Simple Summary Genomic driver alterations with potential impact on prognosis and
treatment response are increasing in non-small cell lung cancer (NSCLC). However, few …

A fitness landscape is a map between the genotype and its reproductive success in a given
environment. The topography of fitness landscapes largely governs adaptive dynamics …

Understanding protein sequence and structure is essential for understanding protein–
protein interactions (PPIs), which are essential for many biological processes and diseases …