Abstract The dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters,
which are collectively referred to as monoamine transporters (MATs), play significant roles in …

Monoamine transporters (MATs) regulate neurotransmission via the reuptake of dopamine,
serotonin and norepinephrine from extra-neuronal regions and thus maintain …

Human serotine transporter (hSERT) is one of the most influential drug targets, and its
allosteric modulators (eg, escitalopram) have emerged to be the next-generation medication …

The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and
chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target …

Depression is a common mental disorder. The standard medical treatment is the selective
serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of …

Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by
increasing the local concentrations of neurotransmitters at synapses and in extracellular …

The dopamine transporter (DAT) is crucial for regulating dopamine signalling and is the
prime mediator for the rewarding and addictive effects of cocaine. As part of the …

The norepinephrine transporter (NET) plays a pivotal role in recycling norepinephrine (NE)
from the synaptic cleft. However, the structures referring to the conformational heterogeneity …

Neurotransmitter transporters (NTTs) are involved in the fine-tuning of brain neurotransmitter
homeostasis. As such, they are implicated in a plethora of complex behaviors, including …

Psychostimulants interacting with the dopamine transporter (DAT) can be used illicitly or for
the treatment of specific neuropsychiatric disorders. However, they can also produce severe …