Introduction: X-ray crystallography plays an important role in structure-based drug design
(SBDD), and accurate analysis of crystal structures of target macromolecules and …

ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in
higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral …

Approximately 10% of human protein kinases are believed to be inactive and named
pseudokinases because they lack residues required for catalysis. Here, we show that the …

Abstract Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children
that can cause severe central nervous system disease and death. No vaccine or antiviral …

Radiation damage inflicted during diffraction data collection in macromolecular
crystallography has re-emerged in the last decade as a major experimental and …

Enzymes with a protein kinase fold transfer phosphate from adenosine 5′-triphosphate
(ATP) to substrates in a process known as phosphorylation. Here, we show that the …

The antibiotic trimethoprim (TMP) is used to treat a variety of Escherichia coli infections, but
its efficacy is limited by the rapid emergence of TMP-resistant bacteria. Previous laboratory …

During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an
RNA-template-bound form and a template-free form to provide the viral polymerase access …

The Hippo pathway controls tissue growth and homeostasis through a central MST-LATS
kinase cascade. The scaffold protein SAV1 promotes the activation of this kinase cascade …

Munc13–1 acts as a master regulator of neurotransmitter release, mediating docking-
priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how …