Lactobacilli and their probiotic effects in the vagina of reproductive age women

S Pendharkar, A Skafte-Holm, G Simsek, T Haahr - Microorganisms, 2023 - mdpi.com
In the present narrative review, the probiotic effects of vaginal Lactobacillus spp. are
described in detail, covering the importance of the differential production of lactic acid, the …

Collectins: innate immune pattern recognition molecules

V Murugaiah, AG Tsolaki, U Kishore - Lectin in host defense against …, 2020 - Springer
Collectins are collagen-containing C-type (calcium-dependent) lectins which are important
pathogen pattern recognising innate immune molecules. Their primary structure is …

A recombinant fragment of human surfactant protein D binds spike protein and inhibits infectivity and replication of SARS-CoV-2 in clinical samples

T Madan, B Biswas, PM Varghese… - American journal of …, 2021 - atsjournals.org
Coronavirus disease (COVID-19) is an acute infectious disease caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Human SP-D (surfactant protein D) is …

Characterization of an air-liquid interface primary human vaginal epithelium to study Ebola virus infection and testing of antivirals

O Escaffre, V Popov, E Hager, AN Freiberg - Antiviral research, 2023 - Elsevier
Ebola virus (EBOV) is the causative agent of the often-fatal Ebola virus disease (EVD)
characterized by hemorrhagic fever in humans and non-human primates. Sexual …

The interplay between cervicovaginal microbial dysbiosis and cervicovaginal immunity

Y Wang, X Wang, M Zhu, L Ge, X Liu, K Su… - Frontiers in …, 2022 - frontiersin.org
The cervicovaginal microbiota plays a key role in the health and reproductive outcomes of
women. In reality epidemiological studies have demonstrated that there is an association …

Poly (dA: dT) suppresses HSV-2 infection of human cervical epithelial cells through RIG-I activation

DD Shao, FZ Meng, Y Liu, XQ Xu, X Wang… - Frontiers in …, 2021 - frontiersin.org
Epithelial cells of the female reproductive tract (FRT) participate in the initial innate immunity
against viral infections. Poly (dA: dT) is a synthetic analog of B form double-stranded (ds) …

Immunocompetent human 3D organ-specific hormone-responding vaginal mucosa model of HIV-1 infection

I Saba, C Barat, S Chabaud, N Reyjon… - … Engineering Part C …, 2021 - liebertpub.com
The lack of appropriate experimental models often limits our ability to investigate the
establishment of infections in specific tissues. To reproduce the structural and spatial …

Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced …

N Beirag, C Kumar, T Madan, MH Shamji… - Frontiers in …, 2022 - frontiersin.org
Lung surfactant protein D (SP-D) and Dendritic cell-specific intercellular adhesion molecules-
3 grabbing non-integrin (DC-SIGN) are pathogen recognising C-type lectin receptors. SP-D …

Innate immune response against HIV-1

V Murugaiah, H Yasmin, H Pandit, K Ganguly… - … : Infection and Immunity, 2021 - Springer
The innate immune system is comprised of both cellular and humoral players that recognise
and eradicate invading pathogens. Therefore, the interplay between retroviruses and innate …

Vaginal epithelium transiently harbours HIV-1 facilitating transmission

VM Prabhu, V Padwal, S Velhal, S Salwe… - Frontiers in Cellular …, 2021 - frontiersin.org
Vaginal transmission accounts for majority of newly acquired HIV infections worldwide. Initial
events that transpire post-viral binding to vaginal epithelium leading to productive infection …