Tourette syndrome: clinical features, pathophysiology, and treatment

KA Johnson, Y Worbe, KD Foote, CR Butson… - The Lancet …, 2023 - thelancet.com
Tourette syndrome is a chronic neurodevelopmental disorder characterised by motor and
phonic tics that can substantially diminish the quality of life of affected individuals. Evaluating …

Tourette's syndrome

J Jankovic - New England Journal of Medicine, 2001 - Mass Medical Soc
The French neurologist Georges Gilles de la Tourette first described this syndrome, which
consists of motor tics sometimes accompanied by uncontrollable noises or utterances …

A neural network for tics: insights from causal brain lesions and deep brain stimulation

C Ganos, B Al-Fatly, JF Fischer, JC Baldermann… - Brain, 2022 - academic.oup.com
Brain lesions are a rare cause of tic disorders. However, they can provide uniquely causal
insights into tic pathophysiology and can also inform on possible neuromodulatory …

Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome

KA Johnson, G Duffley, DN Anderson, JL Ostrem… - Brain, 2020 - academic.oup.com
Deep brain stimulation may be an effective therapy for select cases of severe, treatment-
refractory Tourette syndrome; however, patient responses are variable, and there are no …

Embedded human closed-loop deep brain stimulation for Tourette syndrome: a nonrandomized controlled trial

JN Cagle, MS Okun, S Cernera, RS Eisinger… - JAMA …, 2022 - jamanetwork.com
Importance Because Tourette syndrome (TS) is a paroxysmal disorder, symptomatic relief in
individuals with TS may be possible through the application of stimulation only during the …

Future directions in psychiatric neurosurgery: proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical …

FL Hitti, AS Widge, P Riva-Posse, DA Malone Jr… - Brain Stimulation, 2023 - Elsevier
Objective. Despite advances in the treatment of psychiatric diseases, currently available
therapies do not provide sufficient and durable relief for as many as 30–40% of patients …

Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics …

JK Wong, HS Mayberg, DD Wang… - Frontiers in Human …, 2023 - frontiersin.org
The deep brain stimulation (DBS) Think Tank X was held on August 17–19, 2022 in Orlando
FL. The session organizers and moderators were all women with the theme women in …

Responsive deep brain stimulation for the treatment of Tourette syndrome

MS Okun, J Cagle, J Gomez, D Bowers, J Wong… - Scientific Reports, 2024 - nature.com
To report the results of 'responsive'deep brain stimulation (DBS) for Tourette syndrome (TS)
in a National Institutes of Health funded experimental cohort. The use of 'brain derived …

Deep brain stimulation alleviates tics in Tourette syndrome via striatal dopamine transmission

AE Rusheen, J Rojas-Cabrera, A Goyal, H Shin… - Brain, 2023 - academic.oup.com
Tourette syndrome is a childhood-onset neuropsychiatric disorder characterized by intrusive
motor and vocal tics that can lead to self-injury and deleterious mental health complications …

Increased scale-free and aperiodic neural activity during sensorimotor integration—a novel facet in Tourette syndrome

N Adelhöfer, T Paulus, M Mückschel… - Brain …, 2021 - academic.oup.com
Tourette syndrome is a common neurodevelopmental disorder defined by multiple motor
and phonic tics. Tics in Tourette syndrome resemble spontaneously occurring movements in …