Finding a balance in the vaginal microbiome: how do we treat and prevent the occurrence of bacterial vaginosis?
Bacterial vaginosis (BV) has been reported in one-third of women worldwide at different life
stages, due to the complex balance in the ecology of the vaginal microbiota. It is a common …
stages, due to the complex balance in the ecology of the vaginal microbiota. It is a common …
HIV pathogenesis in the human female reproductive tract
Abstract Purpose of Review Women remain disproportionately affected by the HIV/AIDS
pandemic. The primary mechanism for HIV acquisition in women is sexual transmission, yet …
pandemic. The primary mechanism for HIV acquisition in women is sexual transmission, yet …
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
F Bradley, M Franzén Boger, V Kaldhusdal… - PLoS …, 2022 - journals.plos.org
Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive used
by millions of women worldwide. However, experimental studies have associated DMPA use …
by millions of women worldwide. However, experimental studies have associated DMPA use …
Antigen presenting cells link the female genital tract microbiome to mucosal inflammation, with hormonal contraception as an additional modulator of inflammatory …
EH Byrne, M Farcasanu, SM Bloom, N Xulu… - Frontiers in cellular …, 2021 - frontiersin.org
The microbiome of the female genital tract (FGT) is closely linked to reproductive health
outcomes. Diverse, anaerobe-dominated communities with low Lactobacillus abundance …
outcomes. Diverse, anaerobe-dominated communities with low Lactobacillus abundance …
Women for science and science for women: Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention
Preventing new HIV infections remains a global challenge. Young women continue to bear a
disproportionate burden of infection. Oral pre-exposure prophylaxis (PrEP), offers a novel …
disproportionate burden of infection. Oral pre-exposure prophylaxis (PrEP), offers a novel …
[HTML][HTML] Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD
PM Gupta, C Balle, GK Tharp, SA Nelson, MA Gasper… - Clinical …, 2023 - Elsevier
Although effective contraceptives are crucial for preventing unintended pregnancies,
evidence suggests that their use may perturb the female genital tract (FGT). A comparative …
evidence suggests that their use may perturb the female genital tract (FGT). A comparative …
Spatial transcriptomics unveils estrogen-modulated immune responses and structural alterations in the ectocervical mucosa of depot medroxyprogesterone acetate …
V Kaldhusdal, MF Boger, A Tjernlund, AD Burgener… - Scientific Reports, 2025 - nature.com
The injectable contraceptive, depot medroxyprogesterone acetate (DMPA), is associated
with compromised cervical mucosal barriers. High-resolution spatial transcriptomics is …
with compromised cervical mucosal barriers. High-resolution spatial transcriptomics is …
Sustained immune activation and impaired epithelial barrier integrity in the ectocervix of women with chronic HIV infection
M Franzén Boger, T Hasselrot, V Kaldhusdal… - PLoS …, 2024 - journals.plos.org
Chronic systemic immune activation significantly influences human immunodeficiency virus
(HIV) disease progression. Despite evidence of a pro-inflammatory environment in the …
(HIV) disease progression. Despite evidence of a pro-inflammatory environment in the …
Soluble E‐cadherin: A marker of genital epithelial disruption
R Liu, E Armstrong, S Constable… - American Journal of …, 2023 - Wiley Online Library
Problem The genital epithelial barrier is a crucial first line of defence against HIV, and
epithelial disruption may enhance HIV susceptibility. Assessment of genital epithelial …
epithelial disruption may enhance HIV susceptibility. Assessment of genital epithelial …
Glucocorticoids and medroxyprogesterone acetate synergize with inflammatory stimuli to selectively upregulate CCL20 transcription
JM Moliki, TJ Nhundu, L Maritz, C Avenant… - Molecular and cellular …, 2023 - Elsevier
The pro-inflammatory cytokine, chemokine (CC motif) ligand 20 (CCL20), is emerging as a
therapeutic target for immune-based therapies. Cooperative regulation of CCL20 by …
therapeutic target for immune-based therapies. Cooperative regulation of CCL20 by …