Radiotherapy (RT) has been a classical therapeutic method of cancer for several decades. It
attracts tremendous attention for the precise and efficient treatment of local tumors with …

Conventional cancer therapy strategies, although centered around killing tumor cells, often
lead to severe side effects on surrounding normal tissues, thus compromising the chronic …

Abstract Purpose: Pharmacologic ascorbate (P-AscH−) is hypothesized to be an iron (Fe)-
dependent tumor-specific adjuvant to chemoradiation in treating glioblastoma (GBM). This …

Pharmacological vitamin C (VC) has gained attention for its pro-oxidant characteristics and
selective ability to induce cancer cell death. However, defining its role in cancer has been …

Glioblastoma (GBM), a highly lethal and aggressive central nervous system malignancy,
presents a critical need for targeted therapeutic approaches to improve patient outcomes in …

In recent years, using pharmacological ascorbic acid has emerged as a promising
therapeutic approach in cancer treatment, owing to its capacity to induce extracellular …

Gliomas constitute a diverse and complex array of tumors within the central nervous system
(CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic …

Glioblastoma (GBM), a highly invasive type of brain tumor located within the central nervous
system, manifests a median survival time of merely 14.6 months. Radiotherapy kills tumor …

Magnetic fluid hyperthermia (MFH) is a promising cancer treatment due to its minimal
invasiveness and limited adverse effects. It targets tumor cells by heating them to a specific …

Recently, the FDA-approved iron oxide nanoparticle, ferumoxytol, has been found to
enhance the efficacy of pharmacological ascorbate (AscH−) in treating glioblastoma, as …