Covering: up to the end of 2008 This review discusses the biosynthesis of natural products
that are generated by trans-AT polyketide synthases, a family of catalytically versatile …

Covering: 1953 to September 2005Daptomycin (Cubicin®) is a lipopeptide antibiotic
approved in the USA in 2003 for the treatment of skin and skin structure infections caused by …

Lactobacillus plantarum is a ubiquitous microorganism that is able to colonize several
ecological niches, including vegetables, meat, dairy substrates and the gastro‐intestinal …

Production of secondary metabolites is a process influenced by several physico-chemical
factors including nutrient supply, oxygenation, temperature and pH. These factors have been …

The strengthening and repair of reinforced concrete (RC) civil infrastructure with externally
bonded fibre-reinforced polymer (FRP) composites is an established technology. One of the …

The genetic manipulation of Streptomyces species has been facilitated by the development
of versatile cloning vectors, robust gene transfer systems and transposable elements. These …

Streptomycetes produce useful enzymes and a wide variety of secondary metabolites with
potent biological activities (eg, antibiotics, immunosuppressors, pesticides, etc.). Despite …

Virginiamycin M (VM) of Streptomyces virginiae is a hybrid polyketide-peptide antibiotic with
peptide antibiotic virginiamycin S (VS) as its synergistic counterpart. VM and VS belong to …

The foundation for any strain improvement program is efficient random chemically-induced
mutagenesis coupled with highly reproducible fermentation and product assays. The broad …

Streptomyces noursei ATCC 11455 produces the antifungal polyene antibiotic nystatin
containing the deoxysugar moiety mycosamine. Part of the deoxythymidyl diphosphate …