An N-degron is a degradation signal whose main determinant is a “destabilizing” N-terminal
residue of a protein. Specific N-degrons, discovered in 1986, were the first identified …

Specificity of eukaryotic protein degradation is determined by E3 ubiquitin ligases and their
selective binding to protein motifs, termed" degrons," in substrates for ubiquitin-mediated …

E3 ligase recruitment of proteins containing terminal destabilizing motifs (degrons) is
emerging as a major form of regulation. How those E3s discriminate bona fide substrates …

Ubiquitylation is catalyzed by coordinated actions of E3 and E2 enzymes. Molecular
principles governing many important E3-E2 partnerships remain unknown, including those …

The development of haematopoietic stem cells into mature erythrocytes–erythropoiesis–is a
controlled process characterized by cellular reorganization and drastic reshaping of the …

Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta
and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps …

Multi-subunit E3 ligases facilitate ubiquitin transfer by coordinating various substrate
receptor subunits with a single catalytic center. Small molecules inducing targeted protein …

N-degron pathways are proteolytic systems that target proteins bearing N-terminal (Nt)
degradation signals (degrons) called N-degrons. Nt-Arg of a protein is among Nt-residues …

The C-terminal to LisH (CTLH) complex is a ubiquitin ligase complex that recognizes
substrates with Pro/N-degrons via its substrate receptor Glucose-Induced Degradation 4 …

N-degron E3 ubiquitin ligases recognize specific residues at the N-termini of substrates.
Although molecular details of N-degron recognition are known for several E3 ligases, the …