The oral cavity and oropharynx are complex environments that are susceptible to physical,
chemical, and microbiological insults. They are also common sites for pathological and …

Fosmanogepix is a first-in-class antifungal currently in Phase 2 clinical trials for the treatment
of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix …

Background Fungal infections are responsible for> 1.5 million deaths globally per year,
primarily in those with compromised immune function. This is concerning as the number of …

Probiotics have shown great promise in promoting human health. Despite the promising
evidence, there is little information on the clinical efficacy of many of the available probiotics …

Background Rhino‐orbital‐cerebral mucormycosis (ROCM) is an uncommon yet potentially
lethal fungal infection. Although most cases originate from developing countries, an ageing …

Acute leukemias are a group of aggressive malignant diseases associated with a high
degree of morbidity and mortality. An important cause of both the latter is infectious …

There are limited treatment options for immunosuppressed patients with lethal invasive
fungal infections due to Fusarium and Scedosporium. Manogepix (MGX; APX001A) is a …

Fungi of the genus Fusarium are well known as major plant pathogens and soil inhabitants,
but also cause a broad spectrum of human infections. Fusariosis is the second most …

Opportunistic fungal pathogens can cause a diverse range of diseases in humans. The
increasing rate of fungal infections caused by strains that are resistant to commonly used …

Mortality linked to invasive fungal diseases remains very high despite the availability of
novel antifungals and new therapeutic strategies. C andida albicans and A spergillus …