Making time and space for calcium control of neuron activity
J Jędrzejewska-Szmek, DB Dorman… - Current opinion in …, 2023 - Elsevier
Calcium directly controls or indirectly regulates numerous functions that are critical for
neuronal network activity. Intracellular calcium concentration is tightly regulated by …
neuronal network activity. Intracellular calcium concentration is tightly regulated by …
Multi-scale computational modeling of spatial calcium handling from nanodomain to whole-heart: Overview and perspectives
Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …
excitation-contraction coupling. The calcium spark, the fundamental element of the …
Local Control Model of a Human Ventricular Myocyte: An Exploration of Frequency-Dependent Changes and Calcium Sparks
Calcium (Ca2+) sparks are the elementary events of excitation–contraction coupling, yet
they are not explicitly represented in human ventricular myocyte models. A stochastic …
they are not explicitly represented in human ventricular myocyte models. A stochastic …
Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2G112+5X Mutation in a Guinea Pig Ventricular Myocyte Computational …
Calsequestrin Type 2 (CASQ2) is a high-capacity, low-affinity, Ca2+-binding protein
expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 …
expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 …
Analysis of RyR2 distribution in HEK293 cells and mouse cardiac myocytes using 3D MINFLUX microscopy
AH Clowsley, A Meletiou, E Lučinskaitė, I Jansen… - bioRxiv, 2023 - biorxiv.org
The cardiac type 2 ryanodine receptor (RyR2) is a large homotetramer of a∼ 560 kD subunit
and is the molecular pathway through which the majority of Ca2+ enters the cytosol during …
and is the molecular pathway through which the majority of Ca2+ enters the cytosol during …
Critical requirements for the initiation of a cardiac arrhythmia in rat ventricle: how many myocytes?
Cardiovascular disease is the leading cause of death worldwide due in a large part to
arrhythmia. In order to understand how calcium dynamics play a role in arrhythmogenesis …
arrhythmia. In order to understand how calcium dynamics play a role in arrhythmogenesis …
Modeling Calcium Cycling in the Heart: Progress, Pitfalls, and Challenges
Intracellular calcium (Ca) cycling in the heart plays key roles in excitation–contraction
coupling and arrhythmogenesis. In cardiac myocytes, the Ca release channels, ie, the …
coupling and arrhythmogenesis. In cardiac myocytes, the Ca release channels, ie, the …
Understanding Calmodulin Variants Affecting Calcium-Dependent Inactivation of L-Type Calcium Channels through Whole-Cell Simulation of the Cardiac Ventricular …
Mutations in the calcium-sensing protein calmodulin (CaM) have been linked to two cardiac
arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic …
arrhythmia diseases, Long QT Syndrome 14 (LQT14) and Catecholaminergic Polymorphic …
The Role of Ca2+ Sparks in Force Frequency Relationships in Guinea Pig Ventricular Myocytes
Calcium sparks are the elementary Ca2+ release events in excitation-contraction coupling
that underlie the Ca2+ transient. The frequency-dependent contractile force generated by …
that underlie the Ca2+ transient. The frequency-dependent contractile force generated by …