Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune
systems, significantly influencing various physiological processes such as cell proliferation …

Advances in melanoma research have unveiled critical insights into its genetic and
molecular landscape, leading to significant therapeutic innovations. This review explores the …

Immunotherapy, particularly with immune checkpoint inhibitors, has significantly transformed
cancer treatment. Despite its success, many patients struggle to respond adequately or …

The occurrence of ovarian cancer (OC) is a major factor in women's mortality rates. Despite
progress in medical treatments, like new drugs targeting homologous recombination …

Objective—Despite the advances in oncology, the prognosis of head and neck squamous
cell carcinoma (HNSC) patients remains dismal. In this study, we aimed to determine the …

Immunocheckpoint inhibitors, as an efficient cancer treatment, can only benefit some
patients, so it is still necessary to find a better treatment strategy. As the strongest antigen …

This electronic thesis or dissertation has been downloaded from the King’s Research Portal
at https://kclpure.kcl.ac.uk/portal Page 1 This electronic thesis or dissertation has been …