Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

BRD4 is well known for its role in super-enhancer organization and transcription activation
of several prominent oncogenes including c-MYC and BCL2. As such, BRD4 inhibitors are …

Metastasis is the spread of cancer cells from the primary tumour to distant sites and organs
throughout the body. It is the primary cause of cancer morbidity and mortality, and is …

Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid
leukemia (AML) with MLL translocations. The assumption has been that differentiation is …

Metabolic reprogramming is central to oncogene-induced tumorigenesis by providing the
necessary building blocks and energy sources, but how oncogenic signalling controls …

Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD)
dependent family of monoamine oxidases and is vital in regulation of mammalian biology …

Studies of alterations in histone methylation in cancer have led to the identification of histone
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …

So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Human hematopoietic stem cells (HSCs) exhibit attrition of their self-renewal capacity when
cultured ex vivo, a process that is partially reversed upon treatment with epigenetic …