Stress, overeating, and obesity: Insights from human studies and preclinical models

M Razzoli, C Pearson, S Crow… - … & Biobehavioral Reviews, 2017 - Elsevier
Eating disorders and obesity have become predominant in human society. Their association
to modern lifestyle, encompassing calorie-rich diets, psychological stress, and comorbidity …

Interleukin-1 (IL-1): a central regulator of stress responses

I Goshen, R Yirmiya - Frontiers in neuroendocrinology, 2009 - Elsevier
Ample evidence demonstrates that the pro-inflammatory cytokine interleukin-1 (IL-1),
produced following exposure to immunological and psychological challenges, plays an …

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

T Kreisel, MG Frank, T Licht, R Reshef… - Molecular …, 2014 - nature.com
The limited success in understanding the pathophysiology of major depression may result
from excessive focus on the dysfunctioning of neurons, as compared with other types of …

The impact of everyday stressors on the immune system and health

A Seiler, CP Fagundes, LM Christian - Stress challenges and immunity in …, 2020 - Springer
Research over the past three to four decades has clearly established that psychological
stress affects clinically relevant immune system outcomes, including inflammatory …

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

I Goshen, T Kreisel, O Ben-Menachem-Zidon… - Molecular …, 2008 - nature.com
Several lines of evidence implicate the pro-inflammatory cytokine interleukin-1 (IL-1) in the
etiology and pathophysiology of major depression. To explore the role of IL-1 in chronic …

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

RC Shelton, J Claiborne… - Molecular …, 2011 - nature.com
The etiology of major depression (MDD), a common and complex disorder, remains
obscure. Gene expression profiling was conducted on post-mortem brain tissue samples …

Pro-and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: involvement in depression

Z You, C Luo, W Zhang, Y Chen, J He, Q Zhao… - Behavioural brain …, 2011 - Elsevier
The association between pro-inflammatory cytokines and depression has been reported by
many studies. However, the mechanisms by which inflammation affects mood are only …

Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10

JL Voorhees, AJ Tarr, ES Wohleb, JP Godbout, X Mo… - PloS one, 2013 - journals.plos.org
Altered inflammatory cytokine profiles are often observed in individuals suffering from major
depression. Recent clinical work reports on elevated IL-6 and decreased IL-10 in …

[HTML][HTML] Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools

RS Bains, S Wells, RR Sillito, JD Armstrong… - Journal of neuroscience …, 2018 - Elsevier
An important factor in reducing variability in mouse test outcomes has been to develop
assays that can be used for continuous automated home cage assessment. Our experience …

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

J Hartmann, KV Wagner, C Liebl, SH Scharf… - …, 2012 - Elsevier
Chronic stress is increasingly considered to be a main risk factor for the development of a
variety of psychiatric diseases such as depression. This is further supported by an impaired …