Hemicyanine‐based near‐infrared activatable probes for imaging and diagnosis of diseases

Z Zeng, SS Liew, X Wei, K Pu - Angewandte Chemie, 2021 - Wiley Online Library
Molecular activatable probes with near‐infrared (NIR) fluorescence play a critical role in in
vivo imaging of biomarkers for drug screening and disease diagnosis. With structural …

Activatable molecular probes for second near‐infrared fluorescence, chemiluminescence, and photoacoustic imaging

J Huang, K Pu - Angewandte Chemie International Edition, 2020 - Wiley Online Library
Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering
and autofluorescence in biological tissue between 650–900 nm, conventional optical …

An AIEgen‐peptide conjugate as a phototheranostic agent for phagosome‐entrapped bacteria

G Qi, F Hu, Kenry, L Shi, M Wu… - Angewandte Chemie …, 2019 - Wiley Online Library
The detection and elimination of intracellular bacteria remain a major challenge. In this work,
we report an aggregation‐induced emission (AIE) bioprobe that can detect bacterial …

A palette of minimally tagged sucrose analogues for real‐time Raman imaging of intracellular plant metabolism

F De Moliner, K Knox, D Gordon, M Lee… - Angewandte …, 2021 - Wiley Online Library
Sucrose is the main saccharide used for long‐distance transport in plants and plays an
essential role in energy metabolism; however, there are no analogues for real‐time imaging …

A Fluorescent Activatable AND‐Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis‐Associated Macrophages

A Fernandez, EJ Thompson, JW Pollard… - Angewandte Chemie …, 2019 - Wiley Online Library
We report the novel chemical design of fluorescent activatable chemokines as highly
specific functional probes for imaging subpopulations of immune cells in live tumours …

Synthesis and supramolecular functional assemblies of ratiometric pH probes

A Méndez‐Ardoy, JJ Reina… - Chemistry–A European …, 2020 - Wiley Online Library
Tracking pH with spatiotemporal resolution is a critical challenge for synthetic chemistry,
chemical biology and beyond. Over the last decade, different small probes and …

A highly selective fluorescent probe for detection of hydrogen sulfide in living systems: in vitro and in vivo applications

SI Reja, N Sharma, M Gupta, P Bajaj… - … A European Journal, 2017 - Wiley Online Library
A fluorescein‐based fluorescent probe has been designed and synthesised that selectively
detects H2S in aqueous medium, among various analytes tested. This fluorescein‐based …

A far‐red fluorescent DNA binder for interaction studies of live multidrug‐resistant pathogens and host cells

LN Schulte, B Heinrich, H Janga… - Angewandte Chemie …, 2018 - Wiley Online Library
Transgene expression of green fluorescent protein (GFP) has facilitated the spatiotemporal
investigation of host–pathogen interactions; however, introduction of the GFP gene remains …

A Ratiometric Near‐Infrared Fluorogen for the Real Time Visualization of Intracellular Redox Status during Apoptosis

G Saranya, P Anees, MM Joseph… - … A European Journal, 2017 - Wiley Online Library
Direct monitoring of apoptotic progression is a major step forward for the early assessment
of therapeutic efficacy of certain treatments and the accurate evaluation of the spread of a …

Donor and ring‐fusing engineering for far‐red to near‐infrared triphenylpyrylium fluorophores with enhanced fluorescence performance for sensing and imaging

SY Wen, W Zhang, TB Ren, QL Zhang… - … A European Journal, 2019 - Wiley Online Library
Fluorescent probes have become an indispensable tool in the detection and imaging of
biological and disease‐related analytes due to their sensitivity and technical simplicity. In …