The cellular mechanism (s) underlying autism spectrum disorders (ASDs) are not fully
understood although it has been shown that various genetic and environmental factors …

Glycosylphosphatidylinositol (GPI)-anchored proteins are a specialized class of lipid-
associated neuronal membrane proteins that perform diverse functions in the dynamic …

MDGA (MAM domain containing glycosylphosphatidylinositol anchor) family proteins were
previously identified as synaptic suppressive factors. However, various genetic …

Hippo-YAP signaling pathway functions in early lineage differentiation of pluripotent stem
cells, but the detailed mechanisms remain elusive. We found that knockout (KO) of Mst1 and …

Summary Neuroligin-neurexin (NL-NRX) complexes are fundamental synaptic organizers in
the central nervous system. An accurate spatial and temporal control of NL-NRX signaling is …

Mutations in a synaptic organizing pathway contribute to autism. Autism-associated
mutations in MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) are …

The adult brain is a complex structure with distinct functional sub-regions, which are
generated from an initial pool of neural epithelial cells within the embryo. This transition …

Highlights•MDGAs suppress synapse development by binding to neuroligin-occluding
neurexin interaction.•MDGA1 and MDGA2 interact with all neuroligins with differential …

The adult neocortex is composed of several types of glutamatergic neurons, which are
sequentially born from progenitors during development. The extent and nature of progenitor …

Introduction Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder
characterized by deficits in social interaction, communication and repetitive, restrictive …