METTL protein family: focusing on the occurrence, progression and treatment of cancer

H Zhang, F Sun, S Jiang, F Yang, X Dong, G Liu… - Biomarker …, 2024 - Springer
Methyltransferase-like protein is a ubiquitous enzyme-like protein in the human body, with
binding domains for nucleic acids, proteins and other small molecules, and plays an …

The role of RNA methylation in tumor immunity and its potential in immunotherapy

Y Li, H Jin, Q Li, L Shi, Y Mao, L Zhao - Molecular Cancer, 2024 - Springer
RNA methylation, a prevalent post-transcriptional modification, has garnered considerable
attention in research circles. It exerts regulatory control over diverse biological functions by …

YTHDF1 shapes “cold” tumor and inhibits CD8+ T cells infiltration and function in breast cancer

L Jing, K Zhou, Z Wang, Y Li, Y Fan, T Liu… - Experimental Cell …, 2023 - Elsevier
Abstract While YTH N 6-methyladenosine RNA binding protein 1 (YTHDF1) was recognized
as a crucial contributor in the development and immune-related regulation of various types …

Transcriptome-wide N6-methyladenosine methylation profile of atherosclerosis in mice

X Zheng, B Zhou, Y Li, H Zhong, Z Huang, M Gu - BMC genomics, 2023 - Springer
Background Atherosclerosis (AS) is a critical pathological event during the progression of
cardiovascular diseases. It exhibits fibrofatty lesions on the arterial wall and lacks effective …

Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells

X Zhang, Y Tang, J Wang, M Yang, J Jiang… - Journal of Hazardous …, 2025 - Elsevier
Heat stress negatively affects pig production by disrupting the immune homeostasis of
Sertoli cells (SCs), which compromises sperm quality, culminating in male infertility. Herein …

[HTML][HTML] METTL3 boosts mitochondrial fission and induces cardiac fibrosis after ischemia/reperfusion injury

L Ma, X Chang, J Gao, Y Zhang, Y Chen… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
METTL3, an RNA methyltransferase enzyme, exerts therapeutic effects on various
cardiovascular diseases. Myocardial ischemia-reperfusion injury (MIRI) and subsequently …

N6-Methyladenosine in vascular aging and related diseases: clinical perspectives

C Li, L Liu, S Li, YS Liu - Aging and Disease, 2024 - pmc.ncbi.nlm.nih.gov
Aging leads to progressive deterioration of the structure and function of arteries, which
eventually contributes to the development of vascular aging-related diseases. N6 …

Exploring the molecular mechanisms by which secretory phospholipase a2 regulates lymphatic endothelial cell dysfunction by activating macrophages

Z Zhao, P Li, Z Liu, Y Cui, Z Yao, W Chen… - International Journal of …, 2025 - Elsevier
This study offers new insights into the dual role of secretory phospholipase A2 (sPLA2) in
lymphedema, highlighting its impact on lymphatic endothelial cell (LEC) functionality …

N6-methyladenosine (m6A) modification in Natural immune cell-mediated inflammatory diseases

Y Teng, J Yi, J Chen, L Yang - Journal of Innate Immunity, 2023 - karger.com
The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability,
transport, and translation with implications for various physiological and pathological …

m6A epitranscriptomic modification of inflammation in cardiovascular disease

YS Zhang, ZY Liu, ZY Liu, LC Lin, Q Chen… - International …, 2024 - Elsevier
Cardiovascular disease is currently the number one cause of death endangering human
health. There is currently a large body of research showing that the development of …