Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes tumor
invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma …

Post-translational modification (PTM), the essential regulatory mechanisms of proteins, play
essential roles in physiological and pathological processes. In addition, PTM functions in …

Summary PD-1/PD-L1–targeted immunotherapy has emerged as a promising therapeutic
strategy for pulmonary adenocarcinoma (pADC). Epithelial-to-mesenchymal transition (EMT) …

Non-small cell lung cancer (NSCLC) is characterized by a high incidence of metastasis and
poor survival. As epithelial–mesenchymal transition (EMT) is well recognized as a major …

Long noncoding RNAs (lncRNAs) are dysregulated in many diseases. MicroRNA-101 (miR-
101) functions as a tumor suppressor by directly targeting ZEB1 in various cancers …

Background Epithelial–mesenchymal transition (EMT) is often linked with carcinogenesis.
However, EMT is also important for embryo development and only reactivates in cancer …

Intra-tumor heterogeneity may be present at all molecular levels. Genomic intra-tumor
heterogeneity at the exome level has been reported in many cancer types, but …

Epithelial-mesenchymal transition (EMT) is an important step leading to invasion and
migration of various cancer cells, and are characterized by decreased E-cadherin as an …

Platelet-derived growth factor-BB (PDGF-BB) is recognized as a potential player in a
paracrine manner in tumor stroma development. PDGF-BB has an autocrine growth function …

Increasing evidence suggests that numerous forkhead transcription factors are required to
repress the mammalian cells phenotype. Among them, Foxk2 is a ubiquitously expressed …