Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

Despite the decades-old knowledge that diabetes mellitus is a major risk factor for
cardiovascular disease, the reasons for this association are only partially understood. While …

Proprotein convertase subtilisin/kexin type 9 (PCSK9), mainly synthetized and released by
the liver, represents one of the key regulators of low-density lipoprotein cholesterol …

Over the last 10 years, there have been advances on several aspects of lipoprotein (a)
which are reviewed in the present article. Since the standard immunoassays for measuring …

Purpose of review Based on the recent data of the DA VINCI study, it is clear that, besides
utilization of statins, there is a need to increase non-statin lipid lowering approaches to …

Characterized as a chronic inflammatory disease of the large arteries, atherosclerosis is the
primary cause of cardiovascular disease, the leading contributor of morbidity and mortality …

Abstract Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is involved in cholesterol
homeostasis. After binding to the complex low‐density lipoprotein (LDL)‐receptor, PCSK9 …

This review aimed to trace the inflammatory pathway from the NLRP3 inflammasome to
monomeric C-reactive protein (mCRP) in atherosclerotic cardiovascular disease. CRP is the …

Abstract annually in Europe, 4 million people die from cardiovascular diseases, the main
cause of which is atherosclerosis. In order to slow down the development of atherosclerotic …

910 levels, whereas PCSK9 overexpression did not cause an increase in plasma lipids but
in atherosclerotic lesion size18, 19). The Atheroma IVUS study revealed that the necrotic …