Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …

Red blood cells (RBCs) contain large amounts of iron and operate in highly oxygenated
tissues. As a result, these cells encounter a continuous oxidative stress. Protective …

Alpha (α)-thalassemia is a blood disorder caused by many types of inheritable α-globin
gene mutations which causes no-to-severe clinical symptoms, such as Hb Bart's hydrops …

Plasmodium falciparum malaria kills over 500,000 children every year and has been a
scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum …

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect
against falciparum malaria. Although the protective effect of HbAS against malaria is well …

The malaria parasite has co‐evolved with its human host as each organism struggles for
resources and survival. The scars of this war are carried in the human genome in the form of …

The mechanisms underlying Plasmodium falciparum resistance in persons with sickle trait
have been under active investigation for more than a half century. This Perspective reviews …

Hemoglobin (Hb) variants are associated with reduced risk of life-threatening Plasmodium
falciparum malaria syndromes, including cerebral malaria and severe malarial anemia …

Background: The long co-evolution of Homo sapiens and Plasmodium falciparum has
resulted in the selection of numerous human genetic variants that confer an advantage …