The immune system plays a key role in the development, establishment, and progression of
head and neck squamous cell carcinoma (HNSCC). A greater understanding of the …

A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was
recently implicated in various autoimmune disorders. Tregs are responsible for the …

Colorectal cancer (CRC) represents the third most common malignancy and the second
leading cause of cancer-related deaths worldwide. Although immunotherapy has taken …

Regulatory T cells (Tregs) are central to the maintenance of self-tolerance and tissue
homeostasis. Markers commonly used to define human Tregs in the research setting include …

Tumours express a range of antigens, including self-antigens. Regulatory T cells are crucial
for maintaining T-cell tolerance to self-antigens. Regulatory T cells are thought to dampen T …

Mesenchymal stem cells (MSCs) inhibit the proliferation of HLA-unrelated T lymphocytes to
allogeneic stimulation, but the mechanisms responsible for this activity are not fully …

Background An oncolytic herpes simplex virus engineered to replicate selectively in tumor
cells and to express granulocyte–macrophage colony-stimulating factor (GM-CSF) was …

At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide with a poor
prognosis and one for which immunotherapy remains a viable option. Experimental tumor …

In addition to CD4+ regulatory T cells (Tregs), CD8+ suppressor T cells are emerging as an
important subset of regulatory T cells. Diverse populations of CD8+ T cells with suppressive …