Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …

Platelets play a critical role in hemostasis and thrombus formation. Platelets are small,
anucleate, and short-lived blood cells that are produced by the large, polyploid, and …

Growth factor independence 1 (GFI1) and the closely related protein GFI1B are small
nuclear proteins that act as DNA binding transcriptional repressors. Both recognize the …

Diagnosis of inherited bleeding disorders (IBDs) remains challenging, especially in the case
of inherited platelet disorders, due to the heterogeneity of the clinical and laboratory …

Abstract Background Inherited platelet disorders (IPDs) are a heterogeneous group of rare
diseases that are caused by the defects in early megakaryopoiesis, proplatelet formation …

The bone marrow is responsible for producing an incredible number of cells daily in order to
maintain blood homeostasis through a process called hematopoiesis. Hematopoiesis is a …

Inherited bleeding disorders (IBDs) comprise an extremely heterogeneous group of
diseases that reflect abnormalities of blood vessels, coagulation proteins, and platelets …

Dominant-negative mutations in the transcription factor Growth Factor Independence-1B
(GFI1B), such as GFI1B Q287*, cause a bleeding disorder characterized by a plethora of …

Abstract The transcription factor Growth Factor Independence 1B (GFI1B) recruits Lysine
Specific Demethylase 1 A (LSD1/KDM1A) to stimulate gene programs relevant for …

Abstract Background Inherited thrombocytopenias (ITs) are a heterogeneous group of
disorders characterized by low platelet counts and often disproportionate bleeding with over …