Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Background The human taste experience is the result of five basic taste qualities, namely
sweet, salty, bitter, sour and umami. Sweet, bitter, and umami are mediated by G protein …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

Abstract Sphingosine-1-phosphate (S1P) is an important bioactive lipid molecule in cell
membrane metabolism and binds to G protein-coupled S1P receptors (S1PRs) to regulate …

G-protein-coupled receptors (GPCRs) are involved in numerous physiological processes
and are the most frequent targets of approved drugs. The explosion in the number of new …

The> 800 human G protein–coupled receptors (GPCRs) are responsible for transducing
diverse chemical stimuli to alter cell state-and are the largest class of drug targets. Their …

Highlights•GPCRs are key players in cell-cell communication and pass the signal via
coordinated action of switches.•There are two types of switches: toggle switches and …

Over the past two decades, the opioid epidemic in the United States and Canada has
evidenced the need for a better understanding of the molecular mechanisms of medications …

The development of safe therapeutics to manage pain is of central interest for biomedical
applications. The fluorinated fentanyl derivative N-(3-fluoro-1-phenethylpiperidin-4-yl)-N …

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs)
bind to extracellular ligands and drugs and modulate intracellular responses through …